This paper investigates the optimal control solution using MPC for a typical offshore topside de-oiling process. By considering the combination of the upstream three-phase gravity separator and the downstream de-oiling hydrocyclone set-up as one integrated plant, the plant-wide control problem is formulated and handled using MPC technology. The de-oiling dynamics of the hydrocyclone are estimated via system identification while the key dynamics of the considered gravity separator are modeled based on mass balance and experimental parameter estimation. The developed MPC solution is simulated and experimentally validated via a lab-scaled pilot plant. The comparison of performances of the MPC controlled system with those of a PID controlled system, which emulates the commonly deployed control solution in most current installations, shows the promising results in optimally balancing the gravity separator's (level) control and hydrocyclone's (PDR) control.