Reverse Logistics (RL) of end-of-use/end-of-life products has become a vital part of circular economy practices for manufacturers. However, significant quantities of resources are still landfilled instead of being recovered. With mounting pressure on businesses to address the sustainability crises (resources, climate change, waste, toxicity) on account of the take-make-dispose-based linear economy, companies today realise the importance of RL but face several barriers to implementing it, including a lack of knowledge. Although several studies have investigated different aspects of RL in various industries in different country settings, less attention has been devoted to developing a systematic and holistic approach for designing and implementing RL. To address these gaps, this paper reviews 116 scholarly articles published between 2011 and 2021 to identify attributes related to the design and implementation of RL systems. Based on a systematic literature review, a conceptual framework is presented covering the key activities, drivers and barriers, stakeholder engagement and performance management in RL. Such a framework can support companies evaluate different approaches and strategies, as well as the opportunities and challenges of designing and implementing RL and transitioning towards a Circular Economy.